中医中药药理学外文版 (19).pdf
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1、Antipsychotics Objectives Be able to explain the action,mechanism,therapeutic uses and adverse effects of chlorpromazine Be able to discuss the drug selection for different conditions of patients with checking the textbooks and other materials Identify the typical antipsychotics and atypical antipsy
2、choticsSchizophrenia a particular type of psychosis that is,a mental disorder caused by some inherent dysfunction of the brain Positive symptoms Negative symptoms mesolimbic or mesocorticaldopaminergic neurons.DA receptor hyperfunction5-HT receptor dysfunction?Dopaminergic neuronal pathways and majo
3、r functions A.Substantia nigra-neostriatum:regulation of extrapyramidal motor function B.Mesocortical and Mesolimbic:Ability to regulate cognition,thought,feeling,understanding and reasoning Regulates emotions and emotional expression activities C.Pulvinarinfundibulum:Regulates pituitary hormone sec
4、retionMechanism of action Dopamine receptor blocking activity in the mesolimbic and mesocortical system:chlorpromazine blocks D2 Serotonin receptor blocking activity Clozapine D2blocker,5-HT 2Ablocker Resperidone 5-HT2A,D2blockerAntipsychotics First generation(typical)CPZ Fluphenazine haloperidol Se
5、cond generation(atypical)Aripiprazole Clozapine Olanzapine Paliperidone Risperidone Chlorpromazine:Actions First drug,1952 Antipsychotic actions CNS:Mental patients:Rapidly control the patients excitement and agitation,eliminate the patients hallucinations and delusions,and relieve mental disorders
6、and rational recovery.Actions Antiemetic effects Blocking D2 receptor of chemoreceptor trigger zone of the medulla Chlorpromazine has no effect on the vertigo and motion sicknessActions Alter the temperature-regulating system Poikilothermia body temperature varies with the environment Characteristic
7、s:not only reduce the body temperature of fever,but also reduce the normal body temperature(note:the comparison with antipyretic analgesics)Homeothermia PoikilothermiaCPZActions on autonomic nervous system Side effects Blocking receptor:POSTURAL HYPOTENTION Blocking M receptor:anticholinergic effect
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