参麦注射液对病毒性心肌炎患者血清细胞因子与心率变异性的影响观察.docx
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1、参麦注射液对病毒性心肌炎患者血清细胞因子与心率变异性的影响观察崔福胜王义文张旭表1两组治疗前后血清细胞因子水平变化比拟(士,)*与治疗附比拟.0。5组别TNF-a (ng/IJI1.-6 (ng/IJI1.-I 3 ( pg/ml.)治疗而治疗后治疗前治疗后治疗前治疗后对照组(”=43) 观察组(n=43 ),他41125 35.02183.24 4 12.03,412.65 35.00114.12 13.211.24023.6520.2100.00()65.72 47.4166.01 7.521.3320.18524.65 5.53*15.02 2.23*10,324().(XX)30.12
2、 5.3230.09 5.231.2040.20123.65 1 6.65,18.12 4.32*9.6370.000*与治疗前比拟.0.()5表2两组治疗前后心肌损伤标志物水平变化比拟dtx)组别CK-MB(IU/L),Tnl( ng/L )MYO ( ng/ml.)I.DII ( IU/1J治疗前治疗后治疗前治疗后治疗前治疗后治疗前治疗后对照组(“=43 ) 观察组(”=43 ) ,值46.12 5.3246.00 5.201.4530.32118.903.6510.82 2.12*12.3040.00015.12 4.2015.10 4.230.0390.074147 0.620.72
3、0.1023.54X0.00048.10 9.6528.96 7.14*178.75 8.8548.23 9.7423.04 5.21178.69 8.781.12315.3271.1740.4020.0000.204127.65 8.02*106.44 7.142I.69X0.000与治疗与比拟.P0. 05);治疗后,两组各项指标均 降低,且观察组指标水平均低于对照组,差异均有统计学意义(P0. 05);治疗后,两组各项指标水平均降低,且观察组指标水平均低 于对照组,差异均有统计学意义(P0. 05);治疗后,两组各项指标均升高,且观察组SDNN、SDANN及RMSSD均高于对照组(P0.
4、05) o结论:参麦注射液用于病毒性心肌炎治疗中,对心肌具有保护作 用,不良反响小,平安性高,改善了患者机体迷走神经功能,各项指标水平的 变化可以作为临床治疗指导的参考依据。【Key】病毒性心肌炎参麦注射液血清细胞因子心率变异性不良反响Abstract Objective: To investigate the therapeutic effect of Shenmai Injection on patients with viral myocarditis and its effect on serum cytokines and heart rate variabi1ity (HRV) .
5、 Method: A total of 86 patients with viral myocarditis admitted and treated in Dandong First Hospital from February 2019 to January 2021 were selected as the research subjects. According to the random number table method grouping principle, patients were divided into control group and observation gr
6、oup, with 43 cases in each group. The control group was treated with conventional treatment, while the observation group was treated with Shenmai Injection on the basis of conventional treatment, 14 d as a course of treatment, for a course of treatment. The levels of serum cytokines interleukin-1 3
7、(IL- 1S ) , interleukin-6 (IL-6) , tumor necrosis factor (TNF-a ) and myocardial injury markers creatine kinase isoenzyme (CK-MB), cardiac troponin I (cTnl) , myoglobin (MYO) , lactate dehydrogenase (LDH) in two groups were analyzed before and after treatment, the change of heart rate variability in
8、dexes (SDNN,SDANN, RMSSD) were counted, and the adverse reactions after treatment were compared between the two groups. Result: There were no significant differences in serum cytokines IL_1B , IL-6 and TNF- a between the two groups before treatment (P0.05) ; after treatment, all indexes of the two g
9、roups were decreased, and those of the observation group were lower than those of the control group, the differences were statistically significant (P0. 05) ; the levels were all decreased after treatment, those of the observation group were lower than those of the control group the control group, t
10、he differences were statistically significant(P0. 05) ; and they all increased after treatment, and SDNN, SDANN and RMSSD of the observation group were higher than those of the control group (P0. 05) . Conclusion: In the treatment of viral myocarditis, Sheninai Injection has a protective effect on m
11、yocardiu, with small adverse reactions and high safety, and has improved the vagus nerve function of patients, the changes in the levels of various indicators can be used as a reference for clinical treatment guidance.Key words Viral myocarditis Shenmai Injection Serum cytokines Heart rate variabili
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- 关 键 词:
- 注射液 病毒性 心肌炎 患者 血清 细胞因子 心率 变异性 影响 观察
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